Walailak University’s School of nursing is hosting the 2 ^nd  International  Online Conference  2023 on “ Volatility, Uncertainty, Complexity, and Ambiguity (VUCA) World : Challenge of Nursing Care” on March 29 ^th , 2023. The purpose of this conference is 1) to illuminate the challenges facing nurse in primary, secondary, and tertiary care 2) to share the best practice and discuss solution for challenges and 3) to provide a virtual platform for global researchers, experts, and practitioner to showcase their work. This conference has many theme such as chronic illness management, mental health and mental illness, health promotion and prevention and Nursing education. The first session of this conference is hosted by Professor Dr. Linda Denise Oakley, speaker from University of Wisconsin-Madison. Next session is hosted by Assistant professor Ns. Wiwin Winarti, speaker form UPN Veteran Jakarta University. Finally the final session is hosted by Professor Dr. Sirion Sindhu, speaker from The Nurse Association of Thailand. Many people such as health practioner, lecturer, nursing student from Thailand and oversea also participate in this event.